Abstract Progranulin (PGRN) is a pleiotropic protein that has gained the Twin Bed attention of the neuroscience community with recent discoveries of mutations in the gene for PGRN that cause frontotemporal lobar degeneration (FTLD).Pathogenic mutations in PGRN result in null alleles, and the disease is likely the result of haploinsufficiency.Little
Genetic mutations of FUS have been linked to many diseases including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration.A primate specific and polymorphic retrotransposon of the SINE-VNTR-Alu (SVA) family is present upstream of the FUS gene.Here we Novelties have demonstrated that this retrotransposon can act as a classical t
Trabecular bone structure has an important influence on bone strength, but little is known Twin Bed about its genetic regulation.To elucidate the genetic factor(s) regulating trabecular bone structure, we compared the trabecular bone structures of two genetically remote mouse strains, C57BL/6J and Japanese wild mouse-derived MSM/Ms.Phenotyping by X
Elasmobranchs display various reproductive modes, which have been key to their evolutionary success.In recent decades there has been a rise in the number of reported cases of foetal abnormalities including fertilised, double-embryos held within one egg capsule, hereafter referred to as twins.Previously, the occurrences of twin egg cases have been r
Background & objectives: statistical modeling explicates the observed changes in data by means of mathematics equations.In cases that dependent variable is count, Poisson model is applied.If Poisson model is Audio Amplifiers not applicable in a specific situation, it is better to apply the generalized Poisson model.So, our emphasis in this study is